Lisbon, said to have been founded by Ulysses as Olisipo, is one of Europe's most fascinating cities. A devastating 1755 earthquake destroyed much of it, and the Baixa was rebuilt in neo-classical style, now the city's heart. Overlooking the Tagus, the "City of Explorers" offers districts like Alfama, with Moorish lanes, and Bairro Alto, where you can hear Fado. Nearby are the palaces of Queluz and Sintra.

Portimão offers a relaxing beach getaway framed by golden sands and impressive cliffs. History and architecture lovers can visit the medieval Castle of Alvor and the 14th-century Igreja da Nossa Senhora da Conceição, restored after a devastating earthquake with a walnut-wood altar and azulejo religious scenes. Nature brings cultivated fields, pine-covered slopes, and wildflowers. Take home traditional lace, ceramics, leather goods, and baskets.

Cádiz, Andalusia's famed capital, has been beautifully restored. Palm trees, elegant squares, flower-filled parks, red-tile rooftops, and lively markets give the port a charming feel. Its old town sits on the peninsula tip, full of lively plazas, while the new town is an elegant modern city with excellent beaches. Cádiz is also a good base for a day trip to Seville, home to the Alcazar, Seville Cathedral, and the Giralda Tower.

Málaga, on Spain's Costa del Sol, is the region's capital and a popular holiday base. It is Picasso's birthplace, and his works are displayed in the Museo Picasso in the Palacio de Buenavista. Visitors can also sample sweet Málaga dessert wines from nearby hillside vineyards. The city is a pleasant place to explore and a common starting point for trips to Granada and the Alhambra in the Sierra Nevada foothills.

Málaga, on Spain's Costa del Sol, is the region's capital and a popular holiday base. It is Picasso's birthplace, and his works are displayed in the Museo Picasso in the Palacio de Buenavista. Visitors can also sample sweet Málaga dessert wines from nearby hillside vineyards. The city is a pleasant place to explore and a common starting point for trips to Granada and the Alhambra in the Sierra Nevada foothills.

Almería is thought to have inspired John Lennon's "Strawberry Fields Forever" and was also a filming location for "Lawrence of Arabia." Its top attraction is the Alcazaba, a huge fortress with sweeping views. The cathedral and Almería Museum are also worth seeing, and nearby you can explore the quiet Cabo de Gata-Níjar coast or head west to Roquetas de Mar.

Savor this delightful old city spread over seven hills and its many attractions reflecting the influence of its numerous rulers. Climb to the citadel; visit the fabulous Archaeological Museum, Roman ruins and Pisan towers, early Byzantine churches, the Cathedral or the Botanic Gardens. Enjoy the nearby beach or discover the remains of Sardinia's ancient, enigmatic Nuraghe culture, their villages and huge burial caves.

Travel across millennia as you visit the ruins of ancient Carthage and the opulent, historic medina with its winding alleys and souks. Visit the superb Bardo Museum with its spectacular Roman mosaics or the lovely whitewashed village of Sidi Bou Saïd perched on a cliff above the sea, a charming spot of cobbled streets, flower-filled courtyards and ornate window grills painted deep blue. Enjoy looking for interesting jewelry, caftans and inlaid boxes.

With archaeological sites like Selinunte and Segesta; the mountaintop medieval town of Erice, overlooking the Egadi archipelago; and nearby Marsala, with its House of Mosaics and renowned wine, Trapani lets visitors experience Sicily with all their senses. Don't miss a day trip through the scenic countryside to local olive farms, where cooking demonstrations become delicious repasts and lasting gastronomic memories.

Malta's capital and major port, Valletta was inscribed as a UNESCO World Heritage Site in 1980. Highlights include the 19th-century Mosta Dome, San Anton Palace Gardens in Attard, Lija and Balzan, and the sea views from Dingli Cliffs. Valletta also makes a good base for day trips to Mdina, with St. John's Baroque Cathedral, and Rabat, once part of Roman Melita, with its archaeological sites.