One of Europe's most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona's passionate ambiance at a flamenco show.

Located in southeastern France, today's Marseille is a far cry from the sleepy villages it once inspired in Cézanne's paintings. With more than a million people, the city remains the cosmopolitan and exuberant capital of southern Europe, with its picturesque Old Quarter, lively sidewalk cafes and shops, and Romanesque-Byzantine Notre Dame de la Garde Basilica, overlooking the steep cliffs and offering a bird's eye view of the city's colorful "quartiers" stretching down toward the sea.

Enjoy the exquisite Provençal countryside beyond the resort, with charming villages, narrow stepped streets, lovely churches, and stunning views. Visit a local winery or drive along the rugged coast for landscapes, beaches, islands, and the Massif des Maures. Browse elegant boutiques for French perfume, fine jewelry, fashion, and leather goods. Try local lobster with chilled white wine or lavender ice cream.

Between Nice and Monaco, this low-key Côte d'Azur gem is one of France's most picturesque medieval villages. Its Old Town spills from green hills to a deep-blue harbor, with cobbled lanes, film-set houses, and flowers at every turn. See Jean Cocteau's murals in the 14th-century Chapelle St. Pierre, then the galleries and museums of the 16th-century Citadelle St. Elme, with works by Picasso, Miró, Hartung, and more. Or simply dine by the harbor and enjoy the view.

Picturesquely set in a narrow cove, this tiny port is famed for its beautiful setting, mild climate, and lush vegetation. Crowded around a small harbor, it is among the most beautiful Mediterranean ports and a longtime haunt of the wealthy, artists, and actors. Don't miss Chiesa di San Giorgio and Castello Brown with its garden and harbor views.

Livorno in Tuscany is a gateway to Florence and Pisa. From the 13th to 16th centuries, Renaissance freedom inspired Dante, Donatello, Michelangelo, Giotto, Botticelli, da Vinci, and Machiavelli. In Florence, see the Galleria dell'Accademia and Michelangelo's David, plus the Uffizi, Italy's famed art gallery. Visit Pisa's Campo dei Miracoli, Siena's medieval charm, and Lucca, where you can bike through the Tuscan countryside.

Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.

Discover chic Positano, with its relaxed sophistication, white Moorish-style houses on steep slopes, and a sparkling bay dotted with colorful fishing boats. Then visit enchanting Amalfi to see the 12th-century Capuchin monastery, the 11th-century Cathedral and cloister, and explore on your own. Browse Positano's boutiques for locally made cotton clothes or find souvenirs in Amalfi. Enjoy fresh seafood, pasta, pastries, and espresso in a stunning seaside mountain setting.

With archaeological sites like Selinunte and Segesta; the mountaintop medieval town of Erice, overlooking the Egadi archipelago; and nearby Marsala, with its House of Mosaics and renowned wine, Trapani lets visitors experience Sicily with all their senses. Don't miss a day trip through the scenic countryside to local olive farms, where cooking demonstrations become delicious repasts and lasting gastronomic memories.

Malta's capital and major port, Valletta was inscribed as a UNESCO World Heritage Site in 1980. Highlights include the 19th-century Mosta Dome, San Anton Palace Gardens in Attard, Lija and Balzan, and the sea views from Dingli Cliffs. Valletta also makes a good base for day trips to Mdina, with St. John's Baroque Cathedral, and Rabat, once part of Roman Melita, with its archaeological sites.

Kotor is a coastal town in Montenegro, located in a most secluded part of the Gulf of Kotor. The old port, surrounded by an impressive city wall built by the House of Nemanjicc, is very well preserved and is a UNESCO World Heritage site. Numerous other attractions include the Cathedral of Saint Tryphon in the old town (built in 1166), and ancient walls which stretch directly above the city. Nightlife also attracts tourists to Kotor with pubs, taverns, cafes, and nightclubs.

Found on the northern Dalmatian coast of Croatia, Zadar is rich with thousands of years of history. Ruled at various times by the Romans, Ostrogoths, and Byzantium, the city became a center of commerce and naval power rivaling that of Venice. Today, Zadar's history, culture, and architecture draw visitors from around the world, as does Plitvice National Park, a UNESCO World Heritage Site.

From Fusina, journey to Venice, where you'll witness the Grand Canal, lined with enchanting Renaissance architecture. Art lovers can visit the Peggy Guggenheim Collection or the Doge's Palace, a Gothic masterpiece. Savor Venetian cuisine at a traditional trattoria, sampling fresh local dishes. History enthusiasts can also peruse St Mark's Basilica, a marvelous 18th-century cathedral adorned with sculptures, mosaics and bas-reliefs representing Italian sophistication.