Located in northeastern Italy, Trieste's geography and storied past helped make it one of the country's richest regions. A shopper's paradise, it has designer boutiques for men and women, plus outdoor markets selling everything from fruit to antiques. Enjoy pasta in an old-style osteria, a cozy little place with a handful of tables and cheerful locals.

Found on the northern Dalmatian coast of Croatia, Zadar is rich with thousands of years of history. Ruled at various times by the Romans, Ostrogoths, and Byzantium, the city became a center of commerce and naval power rivaling that of Venice. Today, Zadar's history, culture, and architecture draw visitors from around the world, as does Plitvice National Park, a UNESCO World Heritage Site.

Perched on the Adriatic Sea, the Italian city of Bari has long served as an important port city for both ancient and modern Italy. Today, its rich past attracts visitors from around the world. The Basilica of Saint Nicholas, built in 1087, holds the remains of its namesake beneath the altar, while the Petruzzelli Theatre is one of the grandest opera houses in the country.

Discover charming Argostoli, rising from a turquoise bay beside white limestone hills, with colorful fishing boats, a lively open-air market, and a relaxed atmosphere. Visit the archaeological museum for Mycenaean artifacts, see the Venetian St. George's Castle (16th century) in nearby Kastro, and stroll Vallianos Square for local gifts like thyme honey, gold and silver jewelry, leather goods, and Robola Taoussi white wine.

Monemvasia's Old Town sits on a monolithic island nicknamed the "Gibraltar of the East," a natural fortress that preserved it through time. Cross a narrow causeway to the only entrance to this carefully restored medieval walled town. Wander its car-free cobblestone alleys for a rare glimpse of Greece untouched by time and tourism, then dine with a view on local specialties like fresh pasta, cheese pies, and malvasia, its famed sweet wine.

Santorini's dramatic views-whitewashed houses clinging to the caldera, plus white, red, and black-sand beaches-make it one of the world's most photographed places. Visit Ancient Akrotiri, a town preserved by ash from an eruption 3,600 years ago, and take a day trip to Palea (Old) Kameni and Nea (New) Kameni, two black-lava islands in the center of the Santorini basin.

Mykonos, steeped in Greek myth, was named after Apollo's grandson, Mykons, and linked to the battle between Zeus and the Gigantes. Today it's one of Greece's most beloved destinations, known for its postcard scenery and lively nightlife. It showcases classic Cycladic architecture, with even new buildings required by law to match the whitewashed, cube-like style. Visit Little Venice, Paraportiani Church, and the Delos archaeological site.

Piraeus is the gateway to Athens, the "Cradle of Western Civilization," famed for its lasting cultural and political influence. Driven by tourism and the 2004 Olympics, Greece has redeveloped many sites. Athens remains a historian's delight, with the Acropolis, Parthenon, Plaka's winding streets, the Temple of Olympian Zeus, the Temple of Athena Nike, and the Archaeological Museum's renowned ancient artifacts.

Mykonos, steeped in Greek myth, was named after Apollo's grandson, Mykons, and linked to the battle between Zeus and the Gigantes. Today it's one of Greece's most beloved destinations, known for its postcard scenery and lively nightlife. It showcases classic Cycladic architecture, with even new buildings required by law to match the whitewashed, cube-like style. Visit Little Venice, Paraportiani Church, and the Delos archaeological site.

Europe's classical metropolis, Ephesus, was one of the largest cities in all of the Roman Empire, boasting one of the Seven Wonders of the Ancient World, the Temple of Artemis. Explore the ruins of its massive Theater, the Temple of Hadrian and the magnificent Celsus Library.

Milos boasts over 70 beaches in red, pink, and orange against turquoise seas, plus Sarakiniko's lunar white limestone and Kleftiko's arches and sea caves. In whitewashed Plaka, see a museum with a replica of the Venus de Milo, found on Milos in 1820. In Pollonia, sample wines and cheeses aged in cool volcanic caverns.

Messina, Sicily's third-largest city, was a key medieval port for knights heading to the Crusades. Though extensively rebuilt, it still has major landmarks, especially the cathedral with its unusual astronomical clock, the 12th-century Catania Church, and the ornate Teatro Vittorio Emanuele. It's also a starting point for day trips to Mt. Etna's Crateri Silvestri.

Sorrento is one of the world's most beautiful towns, with breathtaking coastal views and rich history dating back to the 11th century BC. Overlooking the Bay of Naples, it is a key point on the Sorrentine Peninsula and a top destination in Campania. Also plan a day trip to Capri, one of Italy's most celebrated islands, known for its natural beauty.

Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.