Lisbon, said to have been founded by Ulysses as Olisipo, is one of Europe's most fascinating cities. A devastating 1755 earthquake destroyed much of it, and the Baixa was rebuilt in neo-classical style, now the city's heart. Overlooking the Tagus, the "City of Explorers" offers districts like Alfama, with Moorish lanes, and Bairro Alto, where you can hear Fado. Nearby are the palaces of Queluz and Sintra.

Portimão offers a relaxing beach getaway framed by golden sands and impressive cliffs. History and architecture lovers can visit the medieval Castle of Alvor and the 14th-century Igreja da Nossa Senhora da Conceição, restored after a devastating earthquake with a walnut-wood altar and azulejo religious scenes. Nature brings cultivated fields, pine-covered slopes, and wildflowers. Take home traditional lace, ceramics, leather goods, and baskets.

Cádiz, Andalusia's famed capital, has been beautifully restored. Palm trees, elegant squares, flower-filled parks, red-tile rooftops, and lively markets give the port a charming feel. Its old town sits on the peninsula tip, full of lively plazas, while the new town is an elegant modern city with excellent beaches. Cádiz is also a good base for a day trip to Seville, home to the Alcazar, Seville Cathedral, and the Giralda Tower.

Explore the Mendoubia Gardens which contain a fascinating banyan tree that is more than 800 years old. The Caves of Hercules are 9 miles west of Tangier in the Cap Spartel area; it is a place of great beauty and archeological significance.

Málaga, on Spain's Costa del Sol, is the region's capital and a popular holiday base. It is Picasso's birthplace, and his works are displayed in the Museo Picasso in the Palacio de Buenavista. Visitors can also sample sweet Málaga dessert wines from nearby hillside vineyards. The city is a pleasant place to explore and a common starting point for trips to Granada and the Alhambra in the Sierra Nevada foothills.

Cartagena is a Spanish Mediterranean city with more than 2,500 years of history. Each corner, street and square offers travelers monumental examples of its splendorous historical past. The origins of the city are shown at the Punic Wall, which marks the foundation of the city by the Carthaginians in 227 BC. Cartagena has been the capital of the Spanish Navy's Maritime Department of the Mediterranean since the arrival of the Spanish Bourbons in the eighteenth century.

Travel across millennia as you visit the ruins of ancient Carthage and the opulent, historic medina with its winding alleys and souks. Visit the superb Bardo Museum with its spectacular Roman mosaics or the lovely whitewashed village of Sidi Bou Saïd perched on a cliff above the sea, a charming spot of cobbled streets, flower-filled courtyards and ornate window grills painted deep blue. Enjoy looking for interesting jewelry, caftans and inlaid boxes.

With archaeological sites like Selinunte and Segesta; the mountaintop medieval town of Erice, overlooking the Egadi archipelago; and nearby Marsala, with its House of Mosaics and renowned wine, Trapani lets visitors experience Sicily with all their senses. Don't miss a day trip through the scenic countryside to local olive farms, where cooking demonstrations become delicious repasts and lasting gastronomic memories.

Malta's capital and major port, Valletta was inscribed as a UNESCO World Heritage Site in 1980. Highlights include the 19th-century Mosta Dome, San Anton Palace Gardens in Attard, Lija and Balzan, and the sea views from Dingli Cliffs. Valletta also makes a good base for day trips to Mdina, with St. John's Baroque Cathedral, and Rabat, once part of Roman Melita, with its archaeological sites.

Messina, Sicily's third-largest city, was a key medieval port for knights heading to the Crusades. Though extensively rebuilt, it still has major landmarks, especially the cathedral with its unusual astronomical clock, the 12th-century Catania Church, and the ornate Teatro Vittorio Emanuele. It's also a starting point for day trips to Mt. Etna's Crateri Silvestri.

Spend a day exploring the fabulous ruins of ancient Pompeii and Herculaneum with their stunning temples, frescoes and mosaics. Explore fascinating Naples and its famed museums, visit charming Sorrento or take a boat trip to the beautiful Isle of Capri.

Visit this lovely town's 11th-century cathedral with Roman artifacts and Punic burials, then drive the Costa Smeralda for cliffs, grottoes, beaches and emerald waters. Explore Nuraghic ruins, shop for handwoven rugs, baskets, chests, silk shawls and filigree jewelry, and try mussels, lobster in wine, and seadas with honey.

Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.