Panama City blends a shimmering skyline with cobblestone streets, rooftop bars, and centuries-old ruins. Founded in 1519, Panamá Viejo was abandoned in the mid-17th century and replaced by Casco Viejo; together they are a UNESCO Cultural World Heritage site. Visit the Panama Canal Museum for exhibits on the "Big Ditch," and honor the 22,000 workers who died building it at Plaza de Francia.

This bustling city offers open-air markets, striking architecture, and historical museums. In Parque Vargas, amid palms and vine-covered Ficus trees, sloths often move from branch to branch. Ride the aerial tram through Braulio Carrillo National Park's rainforest canopy, or take a boat through the Tortuguero Canals or Estero Negro Estuary, watching for birds, monkeys, iguanas, sloths, crocodiles, and the iridescent Blue Morpho butterfly.

Warm Caribbean waters with excellent diving, white sand beaches, and tropical sunsets are some of the attractions of the Bay Islands. Roatan's major source of income is tourism, particularly because of SCUBA diving attractions. The underwater environment is rich and extensive with reefs surrounding the islands, often within swimming distance of the shore. Caves and caverns are a common feature, with a variety of sponge and the best collection of pillar coral.

This pristine mangrove-covered private island is a gem in the crown of Belize's natural resources. Encounter wildlife and learn about the fauna as you explore the island's mangrove estuaries or snorkel along the reef that surrounds the island. Bask under the warm Caribbean sun on Harvest Caye's untouched sandy beach located on its northern shores; enjoy an exhilarating day of water sports on the lagoon or simple take a stroll along the island village and marina.

Travel from this Guatemalan port city through verdant countryside to Quiriguá's 8th-century stelae and pyramids. Visit Las Escobas Springs in Cerro San Gil, a protected rainforest with 400+ bird species. Explore Rio Dulce National Park in the lush Motagua Valley, then boat to the 17th-century Castle of San Felipe, once guarding Spanish supply ships. Browse Puerto Barrios for local handicrafts and try picante black beans and rice.

Cozumel, Mexico's largest inhabited island, is famed for world-class coral reefs praised by Jacques Cousteau in 1959. Diving is the main draw, but you'll also find Mayan culture, white-sand beaches, and lively neighborhoods. Highlights include the UNESCO-listed ruins of Chichen Itza, the jungle mangroves and Mayan ruins of Faro Celerain Ecological Reserve, and shopping for crafts, jewelry, replicas, cigars, and tequila along Rafael Melgar and Plaza del Sol.

From duty-free shopping and Seven Mile Beach to the Cayman Islands National Museum, Pedro St. James National Historic Site, Queen Elizabeth II Botanic Park, and a rum distillery tour, this quaint capital offers something for everyone.

A relaxing tropical adventure awaits in the heart of Jamaica. Stroll hand-in-hand on perfect white sandy beaches with clear blue skies above. The famous Hip Strip (Jimmy Cliff Boulevard) offers an array of restaurants, bars, and shops. For a taste of the unexpected, explore the Rose Hall Great House, the largest existing sugar plantation mansion, renowned for its haunting tales of the White Witch, Annie Palmer, while sipping a witch's brew.

Sunny Florida skies, year-round warmth, nightlife, and a diverse culture define this cosmopolitan city. South Beach draws crowds, while the Art Deco District is the world's largest collection of Art Deco architecture. Shop from Bal Harbour to Lincoln Road and Coconut Grove, enjoy Cuban culture on Calle Ocho, or visit the historic Venetian Pool. There's something for everyone in this "Gateway to the Americas."