Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.

Spend a day exploring the fabulous ruins of ancient Pompeii and Herculaneum with their stunning temples, frescoes and mosaics. Explore fascinating Naples and its famed museums, visit charming Sorrento or take a boat trip to the beautiful Isle of Capri.

Messina, Sicily's third-largest city, was a key medieval port for knights heading to the Crusades. Though extensively rebuilt, it still has major landmarks, especially the cathedral with its unusual astronomical clock, the 12th-century Catania Church, and the ornate Teatro Vittorio Emanuele. It's also a starting point for day trips to Mt. Etna's Crateri Silvestri.

Malta's capital and major port, Valletta was inscribed as a UNESCO World Heritage Site in 1980. Highlights include the 19th-century Mosta Dome, San Anton Palace Gardens in Attard, Lija and Balzan, and the sea views from Dingli Cliffs. Valletta also makes a good base for day trips to Mdina, with St. John's Baroque Cathedral, and Rabat, once part of Roman Melita, with its archaeological sites.

Alexandria, Egypt's second-largest city and chief harbor, was founded by Alexander the Great in 332 BC. Artifacts are still recovered from its bay. Explore the Roman Catacombs of Kom El Shoqafa, Pompey's Pillar, the Roman Theater, and the Citadel of Qaitbay, built on the site of the ancient Pharos Lighthouse, one of the Seven Wonders. Stroll through the 115-acre Montaza Gardens.

Alexandria, Egypt's second-largest city and chief harbor, was founded by Alexander the Great in 332 BC. Artifacts are still recovered from its bay. Explore the Roman Catacombs of Kom El Shoqafa, Pompey's Pillar, the Roman Theater, and the Citadel of Qaitbay, built on the site of the ancient Pharos Lighthouse, one of the Seven Wonders. Stroll through the 115-acre Montaza Gardens.

Limassol is the jumping-off point for Cyprus's ancient riches: ruins, lemon, orange and olive groves, mountains, and beaches. Visit Lemesos Castle, where Richard the Lionheart married Berengaria of Navarre, and its museum. Explore ancient Curium for mosaics, theater, basilica, and sea views. In Nicosia, see St. John's Cathedral, Venetian fortifications, the old town, mosque, and museum. Shop for lace, copper, jewelry, and pottery, and enjoy appetizers, fresh seafood, and local wine.

Renowned as the site of the former Colossus of Rhodes, one of the Seven Wonders of the Ancient World, Rhodes was home to the Knights of St. John from the 12th to 16th centuries. Their famous Palace of the Grand Masters remains a "must-see," as are many of the inns occupied by the Crusaders and the replica of the old church. For a more in-depth look at the city, visitors can take in the Archeological where the Acropolis of Rhodes and the ancient stadium offer perfect photo opportunities.

Heraklion, Crete's capital, offers two must-sees: the Heraklion Archaeological Museum, with Minoan treasures and artifacts spanning 5,500+ years, and the Palace of Knossos, a Minoan center dating to c.2000 BC and linked to the Minotaur's Labyrinth. Enjoy harbor views from the 13th-century fortress and waterfront, then try fish taverns serving Cretan dishes like kaltsounia with raki.

Europe's classical metropolis, Ephesus, was one of the largest cities in all of the Roman Empire, boasting one of the Seven Wonders of the Ancient World, the Temple of Artemis. Explore the ruins of its massive Theater, the Temple of Hadrian and the magnificent Celsus Library.

Piraeus is the gateway to Athens, the "Cradle of Western Civilization," famed for its lasting cultural and political influence. Driven by tourism and the 2004 Olympics, Greece has redeveloped many sites. Athens remains a historian's delight, with the Acropolis, Parthenon, Plaka's winding streets, the Temple of Olympian Zeus, the Temple of Athena Nike, and the Archaeological Museum's renowned ancient artifacts.

Piraeus is the gateway to Athens, the "Cradle of Western Civilization," famed for its lasting cultural and political influence. Driven by tourism and the 2004 Olympics, Greece has redeveloped many sites. Athens remains a historian's delight, with the Acropolis, Parthenon, Plaka's winding streets, the Temple of Olympian Zeus, the Temple of Athena Nike, and the Archaeological Museum's renowned ancient artifacts.