Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.

Spend a day exploring the fabulous ruins of ancient Pompeii and Herculaneum with their stunning temples, frescoes and mosaics. Explore fascinating Naples and its famed museums, visit charming Sorrento or take a boat trip to the beautiful Isle of Capri.

One of Europe's most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona's passionate ambiance at a flamenco show.

Málaga, on Spain's Costa del Sol, is the region's capital and a popular holiday base. It is Picasso's birthplace, and his works are displayed in the Museo Picasso in the Palacio de Buenavista. Visitors can also sample sweet Málaga dessert wines from nearby hillside vineyards. The city is a pleasant place to explore and a common starting point for trips to Granada and the Alhambra in the Sierra Nevada foothills.

Cádiz, Andalusia's famed capital, has been beautifully restored. Palm trees, elegant squares, flower-filled parks, red-tile rooftops, and lively markets give the port a charming feel. Its old town sits on the peninsula tip, full of lively plazas, while the new town is an elegant modern city with excellent beaches. Cádiz is also a good base for a day trip to Seville, home to the Alcazar, Seville Cathedral, and the Giralda Tower.

Lisbon, said to have been founded by Ulysses as Olisipo, is one of Europe's most fascinating cities. A devastating 1755 earthquake destroyed much of it, and the Baixa was rebuilt in neo-classical style, now the city's heart. Overlooking the Tagus, the "City of Explorers" offers districts like Alfama, with Moorish lanes, and Bairro Alto, where you can hear Fado. Nearby are the palaces of Queluz and Sintra.