Piraeus is the gateway to Athens, the "Cradle of Western Civilization," famed for its lasting cultural and political influence. Driven by tourism and the 2004 Olympics, Greece has redeveloped many sites. Athens remains a historian's delight, with the Acropolis, Parthenon, Plaka's winding streets, the Temple of Olympian Zeus, the Temple of Athena Nike, and the Archaeological Museum's renowned ancient artifacts.

Mykonos, steeped in Greek myth, was named after Apollo's grandson, Mykons, and linked to the battle between Zeus and the Gigantes. Today it's one of Greece's most beloved destinations, known for its postcard scenery and lively nightlife. It showcases classic Cycladic architecture, with even new buildings required by law to match the whitewashed, cube-like style. Visit Little Venice, Paraportiani Church, and the Delos archaeological site.

The tiny island of Bozcaada floats peacefully off the western coast of Turkey in the Dardanelles Strait that connects the Marmara to the Aegean. This charming port boasts untouched bays with a rich marine life, delightful local culture, significant historical heritage, and world-class wine.

Once serving as the capital of the Ottoman and Byzantine Empires, Istanbul today offers impressive architecture, historic sites, dining, shopping, nightlife and exotic atmosphere. Spend time in the Old City to explore renowned places, like the Hagia Sophia, Blue Mosque and Topkapi Palace.

Officially Lesbos, more often Mytilini after its main city, it is Greece's third-largest island, famed for olive oil. Its hills are said to hold 11 million olive trees, silver in the sun, while higher peaks are covered in pine forests. It was the birthplace of major intellectual figures, including Sappho, the great lyric poetess; Pittacus, one of the Seven Sages; Alcaeus, and many others.

Europe's classical metropolis, Ephesus, was one of the largest cities in all of the Roman Empire, boasting one of the Seven Wonders of the Ancient World, the Temple of Artemis. Explore the ruins of its massive Theater, the Temple of Hadrian and the magnificent Celsus Library.

Malta's capital and major port, Valletta was inscribed as a UNESCO World Heritage Site in 1980. Highlights include the 19th-century Mosta Dome, San Anton Palace Gardens in Attard, Lija and Balzan, and the sea views from Dingli Cliffs. Valletta also makes a good base for day trips to Mdina, with St. John's Baroque Cathedral, and Rabat, once part of Roman Melita, with its archaeological sites.

Messina, Sicily's third-largest city, was a key medieval port for knights heading to the Crusades. Though extensively rebuilt, it still has major landmarks, especially the cathedral with its unusual astronomical clock, the 12th-century Catania Church, and the ornate Teatro Vittorio Emanuele. It's also a starting point for day trips to Mt. Etna's Crateri Silvestri.

Sorrento is one of the world's most beautiful towns, with breathtaking coastal views and rich history dating back to the 11th century BC. Overlooking the Bay of Naples, it is a key point on the Sorrentine Peninsula and a top destination in Campania. Also plan a day trip to Capri, one of Italy's most celebrated islands, known for its natural beauty.

Rome offers endless choices: enjoy street performers at the Spanish Steps, wine and people-watching in colorful Trastevere, or the city's rich history and architecture. St. Peter's Basilica is a full-day visit, with the Sistine Chapel and panoramic views from the dome. Don't miss the Trevi Fountain, the Colosseum, and Aventine Hill, which overlooks the Imperial Palaces ruins and the Circus Maximus.

Head out of town to discover five stunning, colorful cliffside towns on the coast. Hike the trail linking them or take a boat tour and see them from the water, as ancient seafarers did. Go ashore to explore a picturesque town and its castle. Or visit Porto Venere, a colorful town above one end of La Spezia's harbor, with breathtaking views and the Church of San Pietro. Once a playground and inspiration for poets from Dante to Byron and Shelley.

Tiny but packed with fun, Monte Carlo blends history, beauty, entertainment, and leisure. Monaco's wealthiest area, it's famed for luxury, celebrity sightings, casinos, and nightlife, yet its old-world charm remains in art and architecture. Palaces, cathedrals, and museums fill this small municipality's historic old town. See the daily changing of the guard, then visit the public areas of the Palais du Prince, home to the royal family and once to Grace Kelly.

One of Europe's most visually stunning cities, Barcelona balances the medieval intimacy of its Gothic Quarter with the grace and distinction of the wide boulevards in the Moderniste Eixample. It was the home of architect Antoni Gaudí, whose Sagrada Familia Cathedral, Park Güell and Casa Milà are the most profound statements of Modernisme. View the splendid works at the Picasso Museum and the Miro Foundation, or discover Barcelona's passionate ambiance at a flamenco show.