Once serving as the capital of the Ottoman and Byzantine Empires, Istanbul today offers impressive architecture, historic sites, dining, shopping, nightlife and exotic atmosphere. Spend time in the Old City to explore renowned places, like the Hagia Sophia, Blue Mosque and Topkapi Palace.

Renowned as the site of the former Colossus of Rhodes, one of the Seven Wonders of the Ancient World, Rhodes was home to the Knights of St. John from the 12th to 16th centuries. Their famous Palace of the Grand Masters remains a "must-see," as are many of the inns occupied by the Crusaders and the replica of the old church. For a more in-depth look at the city, visitors can take in the Archeological where the Acropolis of Rhodes and the ancient stadium offer perfect photo opportunities.

Limassol is the jumping-off point for Cyprus's ancient riches: ruins, lemon, orange and olive groves, mountains, and beaches. Visit Lemesos Castle, where Richard the Lionheart married Berengaria of Navarre, and its museum. Explore ancient Curium for mosaics, theater, basilica, and sea views. In Nicosia, see St. John's Cathedral, Venetian fortifications, the old town, mosque, and museum. Shop for lace, copper, jewelry, and pottery, and enjoy appetizers, fresh seafood, and local wine.

Explore Galilee: the Jordan River, Mount of the Beatitudes, Tabgha, and Nazareth. In Haifa, see the Bahai Gardens and shop at Panorama Center or Massada Street. South of Haifa, Ein Hod offers hand-blown glass, pottery, silver, gold, and crafts. Dining ranges from French and Continental to Middle Eastern, with fresh fish, grilled lamb, and homemade kanafeh-baked sweet cheese with pistachio and honey.

Explore Galilee: the Jordan River, Mount of the Beatitudes, Tabgha, and Nazareth. In Haifa, see the Bahai Gardens and shop at Panorama Center or Massada Street. South of Haifa, Ein Hod offers hand-blown glass, pottery, silver, gold, and crafts. Dining ranges from French and Continental to Middle Eastern, with fresh fish, grilled lamb, and homemade kanafeh-baked sweet cheese with pistachio and honey.

Alexandria, Egypt's second-largest city and chief harbor, was founded by Alexander the Great in 332 BC. Artifacts are still recovered from its bay. Explore the Roman Catacombs of Kom El Shoqafa, Pompey's Pillar, the Roman Theater, and the Citadel of Qaitbay, built on the site of the ancient Pharos Lighthouse, one of the Seven Wonders. Stroll through the 115-acre Montaza Gardens.

Alexandria, Egypt's second-largest city and chief harbor, was founded by Alexander the Great in 332 BC. Artifacts are still recovered from its bay. Explore the Roman Catacombs of Kom El Shoqafa, Pompey's Pillar, the Roman Theater, and the Citadel of Qaitbay, built on the site of the ancient Pharos Lighthouse, one of the Seven Wonders. Stroll through the 115-acre Montaza Gardens.

Piraeus is the gateway to Athens, the "Cradle of Western Civilization," famed for its lasting cultural and political influence. Driven by tourism and the 2004 Olympics, Greece has redeveloped many sites. Athens remains a historian's delight, with the Acropolis, Parthenon, Plaka's winding streets, the Temple of Olympian Zeus, the Temple of Athena Nike, and the Archaeological Museum's renowned ancient artifacts.