Monte Carlo is a glamorous port built for luxury yachts, with some of the world's finest vessels in its harbor. Luxury cars line the winding streets during the Grand Prix, while steep green mountains rise behind the bay. On the cliff stands the Prince's Palace, where the Changing of the Guard draws crowds at 11:55 a.m. Nearby are Monaco Cathedral, with Princess Grace's tomb, the oceanographic museum founded by Prince Albert I, and the Monte Carlo Casino, created by Prince Charles III.

Portofino, with pastel houses around its harbor, is one of Italy's most photographed spots. Highlights include the 12th-century Church of St. George and medieval Castello Brown, both with harbor views. A scenic hike or boat ride leads to the restored 11th-century abbey at San Fruttuoso. Nearby are Genoa, with museums, palaces, and the Cathedral of San Lorenzo, and Cinque Terre, the UNESCO-listed cliffside villages, about an hour away.

Tuscany's countryside is dotted with medieval hill towns, cypress-lined roads, and rolling vineyards. Though Chianti, Brunello, and Vino Nobile are famous worldwide, the region's real draw is its art and architecture. Near Livorno, Florence-the cradle of the Renaissance-offers masterpieces by Dante, Galileo, da Vinci, Raphael, Botticelli, and Donatello. Other beautiful towns include Pisa, Siena, Lucca, and San Gimignano.

Saint-Tropez is famed for designer shopping, all-night nightlife, and luxe beach clubs like Le Club 55 and Nikki Beach. Made famous by Brigitte Bardot, who still lives here, it also has a quieter side in the hills: narrow cobblestone streets and a 17th-century citadel with stunning port views.

Only small ships and yachts can enter Sète's harbor, helping preserve the charm of this French port. Birthplace of Paul Valéry and Georges Brassens, it has a rich artistic heritage, reflected in its museums. Its colorful canals include the northeastern entrance to the Canal du Midi, a UNESCO site linking the Mediterranean and Atlantic. Nearby UNESCO highlights include Arles, inspired Van Gogh, Carcassonne, and Montpellier, known for its historic center and Antigone district by Ricardo Bofill.

Roses, on the Bay of Roses, is famed for tranquil blue waters, 28 miles of beaches, and nine miles of coves. Greeks founded a trading village here in the 5th century BC; remains include Santa Maria monastery. Top sights: the 16th-century Castell de la Trinitat and Catalonia's largest megalithic monument, the Dolmen de la Creu d'en Cobertella. Its west-facing beaches offer memorable sunsets. Try suquet de peix with Empordà wine. Nearby Dalí museums in Port Lligat and Figueres attract art lovers.

Palma, capital of the Balearic Islands, is known for La Seu, the Cathedral of Santa Maria over the bay, the nearby Almudaina Palace, and Bellver Castle, which houses the city museum. The Juan March Foundation Museum has 70 works by major 20th-century Spanish avant-garde artists. Mallorca also offers beaches, shopping on Jaime III and Passeig del Born, and sights like the monastery where George Sand and Chopin stayed and Cuevas del Drach.

Barcelona is a walkable global city known for breathtaking architecture, world-class museums, bustling markets, parks, and fashion. Start at Montjuïc Castle for city views, then visit the Joan Miró and National Art Museum. Spend a day in the Gothic Quarter and Museu Picasso. The city is especially famous for Antoni Gaudí's work, from La Sagrada Família to Park Güell. Along La Rambla, you'll find more architecture, designer shopping, and great tapas.